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KMID : 0974620020200010117
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Bulletin of Dongnam Health University
2002 Volume.20 No. 1 p.117 ~ p.122
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Inhibition of the Contraction of the Rat Uterine Smooth Muscle by Bisphenol A
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Yong Joon-Hwan
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Abstract
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Bisphenol-A(BPA) is used to produce polymers for production of polycarbonate and epoxy resins that are used in food containers and dental appliances. BPA binds to estrogen receptors and induces estrogenic activity in a number of biological systems. The aim of this study was to determine the effects of BPA on uterine smooth muscle contraction of the rat. BPA(1 nM - 100 μM) and β-estradiol(10nM - 100 μM) produced an inhibitory effect on rat uterine strips contraction induced by high KC1(40 mM) in a concentration-dependent manner. The relaxant effect of BPA and 8-estradiol was similar. Also, the contractile effect of oxytocin(10 μM) and carbachol(10 μM) were inhibited by pretreatment with the BPA(10 μM). These results suggest that the relaxant effect of BPA could be related to the inhibition of calcium influx through voltage and ligand-dependent calcium channel.
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